|
Frontotemporal Lobar Degeneration
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This variant is in high LD with the TMEM106B non-synonymous variant p.T185S (rs3173615; r<sup>2</sup> = 0.98) which was previously identified as a protective variant for frontotemporal lobar degeneration (FTLD).
|
31456032 |
2020 |
|
Neurodegenerative Disorders
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In summary, we identified a protective variant in the TMEM106B gene that may have a neuronal protection effect against general aging, independent of disease status, which could help elucidate the relationship between aging and neuronal survival in the presence or absence of neurodegenerative disorders.
|
31456032 |
2020 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Rescue assays verified that TMEM106B overexpression recovered the effects of MAGI2-AS3 inhibition on cell apoptosis, proliferation, and migration in CRC.
|
31709544 |
2020 |
|
Frontotemporal dementia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Age at symptom onset in genetic FTD is variable with recently identified genetic modifiers including TMEM106B (in GRN carriers particularly) and a polymorphism at a locus containing two overlapping genes LOC101929163 and C6orf10 (in C9orf72 carriers).
|
31119452 |
2019 |
|
Frontotemporal dementia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The TMEM106B rs1990622<sup>T</sup> allele, linked to increased risk of FTD, associated with greater MMSE decline over time in PD subjects but not in AD or MCI subjects.
|
30973966 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Pick Disease of the Brain
|
0.100 |
Biomarker
|
disease |
BEFREE |
TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia.
|
30973966 |
2019 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
|
30718901 |
2019 |
|
Impaired cognition
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We evaluate the effect of TMEM106B genotype on cognitive decline across multiple neurogenerative diseases.
|
30973966 |
2019 |
|
Parkinson Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The TMEM106B rs1990622<sup>T</sup> allele, linked to increased risk of FTD, associated with greater MMSE decline over time in PD subjects but not in AD or MCI subjects.
|
30973966 |
2019 |
|
Mental deterioration
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We evaluate the effect of TMEM106B genotype on cognitive decline across multiple neurogenerative diseases.
|
30973966 |
2019 |
|
LEUKODYSTROPHY, HYPOMYELINATING, 16
|
0.600 |
GeneticVariation
|
disease |
CLINVAR |
The recurrent mutation in TMEM106B also causes hypomyelinating leukodystrophy in China and is a CpG hotspot.
|
29444210 |
2018 |
|
LEUKODYSTROPHY, HYPOMYELINATING, 16
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
The recurrent mutation in TMEM106B also causes hypomyelinating leukodystrophy in China and is a CpG hotspot.
|
29444210 |
2018 |
|
Frontotemporal Lobar Degeneration
|
0.400 |
Biomarker
|
disease |
BEFREE |
TMEM106B-related and GFRA2-related pathways might be future targets for treatments for FTLD, but the biological interaction between progranulin and these potential disease modifiers requires further study.
|
29724592 |
2018 |
|
Frontotemporal Lobar Degeneration
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) inherited as one of two common haplotypes at the transmembrane protein 106B (TMEM106B) locus are associated with the risk of multiple neurodegenerative diseases, including frontotemporal lobar degeneration with pathological inclusions of TDP-43.
|
29970152 |
2018 |
|
Frontotemporal dementia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
|
29855382 |
2018 |
|
Frontotemporal dementia
|
0.200 |
Biomarker
|
disease |
BEFREE |
As TMEM106B is a risk factor for frontotemporal dementia caused by both C9orf72 and progranulin mutations, and antisense oligonucleotides are showing promise as therapeutics for neurodegenerative diseases, our data suggests a potential new strategy for treating the wide range of frontotemporal dementias associated with endolysosomal dysfunction.
|
30496365 |
2018 |
|
Frontotemporal dementia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Multiple genome-wide association studies have shown that risk of FTD in GRN mutation carriers is modified by polymorphisms in TMEM106B, which encodes a lysosomal membrane protein.
|
29929528 |
2018 |
|
Dementia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Among CTE cases, TMEM106B minor allele was also associated with reduced ante-mortem dementia (OR = 0.40, 95% CI 0.16-0.99, p = 0.048), but was not associated with TDP-43 pathology.
|
30390709 |
2018 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Pick Disease of the Brain
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
|
29855382 |
2018 |
|
Pick Disease of the Brain
|
0.100 |
Biomarker
|
disease |
BEFREE |
As TMEM106B is a risk factor for frontotemporal dementia caused by both C9orf72 and progranulin mutations, and antisense oligonucleotides are showing promise as therapeutics for neurodegenerative diseases, our data suggests a potential new strategy for treating the wide range of frontotemporal dementias associated with endolysosomal dysfunction.
|
30496365 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Mood Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.
|
29662059 |
2018 |